Sola-Bonada, N., de Andres-Lazaro, A. M., Roca-Massa, M., Bordas-Alsina, J. M., Codina-Jane, C., and Ribas-Sala, J. Take antacids at least two hours after coated peppermint oil products. Nat Prod Res 3-20-2008;22(5):428-439. A pharmacokinetic comparison of two delayed-release peppermint oil preparations, Colpermin and Mintec, for treatment of irritable bowel syndrome. View abstract. Thomas JM, Payne-James J, Carr N, and et al. Consider therapy modification.Juxtapid March 2016, Patel 2016, Nimodipine: CYP3A4 inhibitors (weak) may increase the serum concentration of nimodipine. View abstract. However, no change was observed in the number of cigarettes smoked per day between these 2 periods. Basic Clin Pharmacol Toxicol. Lim, W. C., Seo, J. M., Lee, C. I., Pyo, H. B., and Lee, B. C. Stimulative and sedative effects of essential oils upon inhalation in mice. Effects of dimethylformamide and L-menthol permeation enhancers on transdermal delivery of quercetin. 2011;11(60):425-433. against Trichophyton mentagrophytes. [1.6% peppermint oil solution as intestinal spasmolytic in retrograde endoscopic cholangiopancreatography]. Otolaryngol.Head Neck Surg. Stay hydrated - Staying hydrated may not keep you from having morning sickness, but it will keep you out of the hospital. View abstract. Breast infections (mastitis) are not signs of pregnancy. Some early research shows that inhaling peppermint oil might relieve nausea for up to 4 hours after surgery. Parys, B. T. Chemical burns resulting from contact with peppermint oil mar: a case report. Early research also shows that applying oil containing 0.5% peppermint oil can reduce the severity of itchy skin in women with pregnancy-related itching. View abstract. Cochrane Database Syst Rev 2011;(8):CD003460. Farm Hosp 2012;36(4):256-260. Spasm in the esophagus. View abstract. View abstract. View abstract. Clin J Pain 2002;18(3):200-202. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. View abstract. Avoid combination.Desta 1998, Desta 1999, Flockhart 1996, Orap August 2011, Simvastatin: Peppermint oil may influence metabolism of simvastatin via inhibition of CYP3A4, elevating simvastatin plasma concentrations and increasing pharmacologic and adverse reactions. View abstract. View abstract. There are a variety of peppermint types cultivated worldwide. Naito, K., Komori, M., Kondo, Y., Takeuchi, M., and Iwata, S. The effect of L-menthol stimulation of the major palatine nerve on subjective and objective nasal patency. 20% L-Ascorbic Acid, Ferulic Acid and Kojic Acid work synergistically to improve the appearance of dark spots and uneven skin tone. Pak.J Biol.Sci. View abstract. Am J Gastroenterol 1998;93:1131-5. Research shows that, Indigestion (dyspepsia). Br J Nutr 1999;81:289-95. View abstract. A combination of peppermint oil and caraway oil for the treatment of functional dyspepsia: A systematic review and meta-analysis. Shayegh, S., Rasooli, I., Taghizadeh, M., and Astaneh, S. D. Phytotherapeutic inhibition of supragingival dental plaque. J Clin Periodontol. Benefit may favor lower GI (eg, abdominal pain, bloating, stool consistency, stool frequency, flatulence) over upper GI symptoms (eg, belching, heartburn, nausea).Cappello 2007, Ford 2008, Grigoleit 2005, Hadley 2005, Harris 2006, Huertas-Ceballos 2008, Jailwala 2000, Jones 2006, Kline 2001, Liu 1997, Merat 2010, Pittler 1998, van Zanten 2009 A review of clinical trials investigating dosages of up to 1,200 mg/day of enteric-coated peppermint oil (capsules containing 180 to 200 mg of peppermint oil and administered as 1 to 2 capsules 3 times daily) over 2 to 4 weeks suggested peppermint oil maybe a drug of first choice in patients with nonserious constipation and diarrhea associated with IBS to alleviate general symptoms and improve quality of life.Grigoleit 2005 A 2014 systematic review and meta-analysis of 9 studies (N=726) evaluating peppermint oil for treatment of IBS symptoms support these observations.Khanna 2014 In the Irritable Bowel Syndrome Reduction Evaluation and Safety Trial (IBSREST), which enrolled 72 patients with mixed- or diarrhea-type IBS, a novel capsule formulation incorporating triple-coated microspheres of peppermint oil (180 mg 3 times daily for 4 weeks) designed to provide sustained release in the small intestine was effective in providing rapid relief of IBS symptoms; at 24 hours and 4 weeks, Total IBS Symptom Score was significantly improved compared to placebo, and treatment was well tolerated.Cash 2016, The American College of Gastroenterology position statement on the treatment of IBS (2009) states that peppermint oil appears superior to placebo in treating symptoms of IBS, based on a limited number of studies (n=4) enrolling approximately 400 patients. Z Gastroenterol 2001;39(7):511-7. Environ.Mol.Mutagen. Clin Pharmacol Ther 1988;43(2):173. Spasmolytic effect of peppermint oil in barium during double-contrast barium enema compared with Buscopan. Park, M. K. and Lee, E. S. [The effect of aroma inhalation method on stress responses of nursing students]. Respir.Res 2011;12:92. Welcome to Hemp Life Mag! Peppermint oil 600 mg in water increased the AUC of simvastatin by 30% in healthy volunteers.Dresser 2002, Menthol, the major component of peppermint oil, may cause allergic reactions (eg, contact dermatitis, flushing, headache).Herro 2010, Kawane 1996, Leung 1980, Posadzki 2012, Wilkinson 1994 Delayed patch-test reaction to menthol and peppermint oil may occur 6 to 14 days after application.Fleming 1998 Symptoms of contact sensitivity and ulceration from oral menthol/peppermint-containing products improved with discontinuation and avoidance of these products.Morton 1995 In a crossover study of migraine patients, cutaneous burning sensation (8.3% of migraine attacks), lacrimation (5% of attacks), and aggravation of headache (1.6% of attacks) were most common with menthol; 2 patients in the menthol group discontinued the study due to severe burning sensation and aggravation of headache.Borhani Haghighi 2010, Burns and skin necrosis following topical application of peppermint oil have been reported.Posadzki 2012 Following ingestion of 40 drops of peppermint oil, a patient with no known allergies reported mucosal burns and edema of the tongue and oral cavity.Tamir 2005 Excessive consumption of mint-flavored sweets caused stomatitis with oral papillary hypertrophy.Rogers 1995 Vulval allergic contact dermatitis was documented in a patient who consumed large amounts of peppermint tea.Vermaat 2008 A peppermint foot spray was linked to dermatitis in another patient,Kalavala 2007 and several cases of dermatitis of the lips and mouth were traced to peppermint flavored/menthol-containing lip balm, toothpaste, and throat spray.Bourgeois 2016, Tran 2010 Nonetheless, such peppermint allergies appear to be rare, with prospective patch testing finding no allergic or irritant reactions to either menthol or peppermint oil in 400 subjects.Kanerva 2001 Loss of libido in men following consumption of peppermint tea has been reported.Akdogan 2004, Like other mints from which menthol is derived as a plant extract, peppermint has GRAS status when consumed as a seasoning or flavoring.McKay 2006, Nair 2001 Two comprehensive reports on peppermint safety have been published,Nair 2001, SCF 2002 with pulegone and menthofuran being the constituents of toxicologic concern. Proc.Natl.Acad.Sci.U.S.A 11-25-2003;100(24):14481-14486. Br J Nurs. Control Clin.Trials 1996;17(1):1-12. 2002;65(1):41-43. View abstract. (check all that apply). Lazutka, J. R., Mierauskiene, J., Slapsyte, G., and Dedonyte, V. Genotoxicity of dill (Anethum graveolens L.), peppermint (Menthaxpiperita L.) and pine (Pinus sylvestris L.) essential oils in human lymphocytes and Drosophila melanogaster. Multicentre trial of peppermint oil capsules in irritable bowel syndrome. Gazz Med Ital 2005;164:119-126. View abstract. Gastrointest Endosc 2001;53(2):172-177. Gastroenterology 2007;132 (suppl 1):A141. This serum also contains Hyaluronic Acid and Peptides to reduce the appearance of fine lines and reveal a fuller, brighter look. J Gastroenterol 2007;42(7):539-542. Postgrad Med J 1987;63:717. Mizuno S, Kato K, Ono Y, et al. Peppermint oil should not be administered to patients with gastroesophageal reflux or active gastric ulcers because the oil decreases esophageal sphincter pressure. I: alertness. View abstract. 2002;19(8):571-579. Peppermint oil is an essential oil containing numerous healing properties. View abstract. When race and gender covariates were combined, a significantly lower probability in abstinence was evident in females versus males who smoked menthol cigarettes, particularly black females compared with white females (17% vs 35%, respectively; P<0.0001).Smith 2014 Similarly, a secondary analysis of data from a randomized controlled trial of low-dose naltrexone as an adjunct to nicotine replacement therapy reported significantly lower abstinence rates in menthol versus nonmenthol smokers at both 14 and 26 weeks (P=0.04 each). [Effects of oral care with essential oil on improvement in oral health status of hospice patients]. Umezu, T. and Morita, M. Evidence for the involvement of dopamine in ambulation promoted by menthol in mice. Jadad, A. R., Moore, R. A., Carroll, D., Jenkinson, C., Reynolds, D. J., Gavaghan, D. J., and McQuay, H. J. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Thompson, Coon J. and Ernst, E. Systematic review: herbal medicinal products for non-ulcer dyspepsia. Pak.J Biol.Sci. Chang, F. Y. and Lu, C. L. The clinical significances of irritable bowel syndrome in Taiwan. Altern Ther Health Med 1999;5:42-51. Kline RM, Kline JJ, Di Palma J, Barbero GJ. Ilmberger, J., Heuberger, E., Mahrhofer, C., Dessovic, H., Kowarik, D., and Buchbauer, G. The influence of essential oils on human attention. 2013;19(1):69-71. Basic Clin Pharmacol Toxicol. Leicester RJ, Hunt RH. This information relates to an herbal, vitamin, mineral or other dietary supplement. View abstract. 2003;91(2):125-135. Phytother Res 2007;21(7):641-643. Early research shows that inhaling peppermint oil slightly improves memory and performance on mental tasks, but does not improve attention and speed of completing tasks. View abstract. Complement Ther Med. Top with crushed candy cane bits for an extra minty (and festive!) It is unknown whether peppermint inhibited the CYP2A6 or the aldehyde oxidase step of nicotine metabolism.Ghazi 2011, Aripiprazole: CYP3A4 inhibitors (weak) may increase the serum concentration of aripiprazole. View abstract. Itching. View abstract. Carling L, Svedberg L, and Hultsen S. Short term treatment of the irritable bowel syndrome: a placebo-controlled trial of peppermint oil against hyoscyamine. Hot flashes in people treated for breast cancer. View abstract. Phytother Res 2017;31(1):27-39. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. View abstract. Some medications are changed and broken down by the liver. 1980;171(5):344-347. View abstract. Eccles, R., Griffiths, D. H., Newton, C. G., and Tolley, N. S. The effects of D and L isomers of menthol upon nasal sensation of airflow. Occurrence of menthofuran in oil of peppermint (Mentha piperita vulgaris S.). View abstract. Wilkinson JM. Midwifery 2000;16:224-8. Clin Cosmet Investig Dermatol 2016;9:333-8. J Gastroenterol 1997;32:765-8. View abstract. 2005;12(8):607-611. Meta-analysis: phytotherapy of functional dyspepsia with the herbal drug preparation STW 5 (Iberogast). Although no primary outcome data were reported, a significant effect was reported for peppermint compared to chamomile tea for reduction in total testosterone (P=0.03).Arentz 2017, Menthol is available in a variety of nonprescription products (eg, chest rubs, inhalants, lozenges, syrups) for the treatment of colds and related congestion and cough. 2019;47:102223. A second small study examined the effect of applying peppermint oil on the skin to reduce itching during pregnancy. Black Peppermint, Brandy Mint, Extract of Mentha Piperita, Extract of Peppermint, Extract of Peppermint Leaves, Extract of Peppermint Leaves, Extrait de Feuilles de Menthe de Poivrée, Extrait de Mentha Piperita, Extrait de Menthe Poivrée, Feuille de Menthe Poivrée, Field Mint, Herba Menthae, Huile de Mentha Piperita, Huile de Menthe Poivrée, Huile Essentielle de Menthe Poivrée, Lamb Mint, M. Balsamea, M. Balsamea Willd Extract, Menta Pepperita, Menta Piperita, Mentha Balsamea, Mentha lavanduliodora, Mentha Oil, Mentha Piperita, Mentha Piperita Extract, Mentha Piperita Oil, Mentha x piperita, Menthae Piperitae Aetheroleum, Menthae Piperitae Folium, Menthe, Menthe Poivrée, Menthol, Mint, Mint Balm, Oil of Peppermint, Paparaminta, Peppermint Essential Oil, Peppermint Extract, Peppermint Leaf, Peppermint Leaf Extract, Peppermint Oil, Western Peppermint. View abstract. Lett.Appl.Microbiol. Acta Gastroenterol Belg 2012;75(3):349-353. In a randomized controlled trial, 32% fewer participants taking green tea extract developed cold or flu symptoms compared to a placebo control group (Rowe et al., 2006). Hindustan Antibiot.Bull. When peppermint oil products dissolve too quickly they can sometimes cause heartburn and nausea. 2005;60(11-12):826-832. View abstract. Br J Clin Pharmacol 1984;18:638-40. Naito, K., Ohoka, E., Kato, R., Kondo, Y., and Iwata, S. The effect of L-menthol stimulation of the major palatine nerve on nasal patency. 2006;82(5):331-337. 1988;30(3-4):82-84. Lane, B., Cannella, K., Bowen, C., Copelan, D., Nteff, G., Barnes, K., Poudevigne, M., and Lawson, J.
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